| Alumnus or alumna | Purdue degree(s) | Mission name(s) (STS=Space Shuttle) |
| Neil A. Armstrong | BS '55, Aeronautical Engineering | Gemini-Titan VIII, Apollo 11 ** |
| John E. Blaha | MS '66, Astronautics | STS 29, 33, 43, 58, 79, 81
|
| Roy D. Bridges Jr. | MS '66, Astronautics | STS 51-F |
| Mark N. Brown | BS '73, Aeronautical and Astronautical Engineering | STS 28, 48 |
| John J. Casper | MS '67, Astronautics | STS 36, 54, 62, 77 |
| Eugene A. Cernan | BS '56, Electrical Engineering | Gemini-Titan IX-A, Apollo 10, Apollo 17 *** |
| Roger B. Chaffee | BS '57, Aeronautical Engineering | * |
| Richard O. Covey | MS '69, Aeronautics and Astronautics | STS 51-I, 26, 38, 61 |
| Andrew J. Feustel | MS '91, Earth and Atmospheric Sciences | Began astronaut training in August 2000. Mission assignments pending completion of training program.
| Guy S. Gardner | MS '70, Aeronautics and Astronautics | STS 27, 35 |
| Virgil I. Grissom | BS '50, Mechanical Engineering | Mercury-Redstone 4, Gemini-Titan III * |
| Gregory J. Harbaugh | BS '78, Aeronautical and Astronautical Engineering | STS 39, 54, 71, 82 |
| Michael J. McCulley | BS '70, MS '70, Metallurgical Engineering | STS 34 |
| Gary E. Payton | MS '72, Aeronautics and Astronautics | STS 51-C |
| Mark L. Polansky | BS '78, MS '78, Aeronautical and Astronautical Engineering | STS-98, 116 |
| Jerry Ross | BS '70, MS '72, Mechanical Engineering | STS 61-B, 27, 37, 55, 74, 88,
STS-110
|
| Loren J. Shriver | MS '68, Astronautics | STS 51-C, 31, 46 |
| Janice E. Voss | BS '75, Engineering Science | STS 57, 63, 83, 94, 99 |
| Charles D. Walker | BS '71, Aeronautical and Astronautical Engineering | STS 41-D, 51-D, 61-B |
| Mary E. Weber | BS '84, Chemical Engineering | STS 70; STS-101 |
| Donald E. Williams | BS'64, Mechanical Engineering | STS 51-D, 34 |
| David A. Wolf | BS '78, Electrical Engineering | STS 58, 86, 89 |